Article

Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury

2023-01-09

Abstract excerpt

<h4>ABSTRACT</h4> Neutrophil extracellular traps (NETs) are abundant in sepsis, and proposed NET-directed therapies in sepsis prevent their formation or accelerate degradation. Yet NETs are important for microbial entrapment, as NET digestion liberates pathogens and NET degradation products (NDPs) that deleteriously promote thrombosis and endothelial cell injury. We proposed an alternative strategy of NET-stabili...

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Literature Corpus work: 15ea5f9f-f633-5157-a706-5648af603af5
DOI: 10.1101/2023.01.09.522931

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