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Article

DNAse-dependent, NET-independent pathway of thrombus formation in vivo

6 Jul 2021

Abstract excerpt

The contribution of NETs (neutrophil extracellular traps) to thrombus formation has been intensively documented in both arterial and venous thrombosis in mice. We previously demonstrated that adenosine triphosphate (ATP)-activated neutrophils play a key role in initiating the tissue factor-dependent activation of the coagulation cascade, leading to thrombus formation following laser-induced injury. Here, we...

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PMID: 34260389
DOI: 10.1073/pnas.2100561118

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