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Article

NLRP3 Inflammasome Assembly in Neutrophils Is Supported by PAD4 and Promotes NETosis Under Sterile Conditions

28 May 2021

Abstract excerpt

Neutrophil extracellular trap formation (NETosis) and the NLR family pyrin domain containing 3 (NLRP3) inflammasome assembly are associated with a similar spectrum of human disorders. While NETosis is known to be regulated by peptidylarginine deiminase 4 (PAD4), the role of the NLRP3 inflammasome in NETosis was not addressed. Here, we establish that under sterile conditions the cannonical NLRP3 inflammasome...

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Share to Inflammasome and immune disorders
Share to Neutrophil, Myeloperoxidase and Oxidative Mechanisms
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Identifiers

PMID: 34122445
DOI: 10.3389/fimmu.2021.683803

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