Article
Two Ca(2+)-Binding Sites Cooperatively Couple Together in TMEM16A Channel.
The Journal of membrane biology - 1 Apr 2016
Han Yuebin, Zhang Suhua, Ren Shuxi, Chen Yafei, Yuan Hongbo, Chai Ran, Yu Hui, Zhang Hailin, Zhan Yong, An Hailong
Abstract excerpt
TMEM16A is the molecular basis of calcium-activated chloride channels and shows Ca(2+)-dependent gating. It is critical to understand how the Ca(2+) sensors dynamically control the gate of TMEM16A. However, the detailed mechanism by which the calcium ions bind and open the channel is still obscure. In this study, the authors confirmed that there are two Ca(2+) sensors which cooperatively couple together in...
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