Article
TCR beta allelic exclusion in dynamical models of V(D)J recombination based on allele independence.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2010
Farcot Etienne, Bonnet Marie, Jaeger Sébastien, Spicuglia Salvatore, Fernandez Bastien, Ferrier Pierre
Abstract excerpt
Allelic exclusion represents a major aspect of TCRbeta gene assembly by V(D)J recombination in developing T lymphocytes. Despite recent progress, its comprehension remains problematic when confronted with experimental data. Existing models fall short in terms of incorporating into a unique distribution all the cell subsets emerging from the TCRbeta assembly process. To revise this issue, we propose dynamical,...
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