Article
Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.
Comparative medicine - 1 Oct 2015
Vestergaard Bill, Krych Łukasz, Lund Leif R, Jørgensen Bettina P, Hansen Lars, Jensen Henrik E, Nielsen Dennis S, Hansen Axel K
Abstract excerpt
Plasminogen-deficient (FVB/NPan-plg(tm1Jld), plg(tm1Jld)) mice, which are widely used as a wound-healing model, are prone to spontaneous rectal prolapses. The aims of this study were 1) to evaluate the fecal microbiome of plg(tm1Jld) mice for features that might contribute to the development of rectal prolapses and colonic inflammation and 2) to assess the relevance of the inflammatory phenotype to the...
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