Article

Differential susceptibility to colonic ulceration in mice with genetic deletion of Prostaglandin E synthase

2025-07-07

Abstract excerpt

<title>Abstract</title> <p>Background: Prostaglandin E<sub>2</sub> (PGE<sub>2</sub>) exerts pleiotropic and context-dependent effects on inflammation, cancer and maintenance of intestinal mucosal homeostasis. To further define its role in intestinal diseases, we genetically inactivated its rate-limiting synthesis, <italic>Ptges</italic>, in two mouse lines. An unexpected phenotype consisting of spontaneous mucosa...

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Literature Corpus work: cd2cf016-7f0f-5357-8a2d-ec8a91158c06
DOI: 10.21203/rs.3.rs-6977322/v1

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