Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.

Glia - 1 Feb 2016

Campbell Andrew, Bushman Jared, Munger Joshua, Noble Mark, Pröschel Christoph, Mayer-Pröschel Margot

Abstract excerpt

Astroglial dysfunction plays an important role in neurodegenerative diseases otherwise attributed to neuronal loss of function. Here we focus on the role of astroglia in ataxia-telangiectasia (A-T), a disease caused by mutations in the ataxia-telangiectasia mutated (ATM) gene. A hallmark of A-T pathology is progressive loss of cerebellar neurons, but the mechanisms that impact neuronal survival are unclear. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcysteine
Share to Astrocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cystine

Share to Extracellular Space

Share to Glutathione

Share to Glutathione Reductase

Share to Intracellular Space

Share to Mice, 129 Strain

Source

Open in PubMed Open full text

Identifiers

PMID: 26469940
DOI: 10.1002/glia.22925
PMCID: PMC5580048

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia.PMID 26469940Read ↗

Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytesSemantic proximity Read ↗

ATM phosphorylation of CD98HC increases antiporter membrane localization and prevents chronic toxic glutamate accumulation in Ataxia telangiectasiaSemantic proximity Read ↗

Decreased expression of glutamate transporter GLAST in Bergmann glia is associated with the loss of Purkinje neurons in the spinocerebellar ataxia type 1.Semantic proximity Read ↗

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3.Semantic proximity Read ↗

Impaired glutamate uptake in the R6 Huntington's disease transgenic mice.Semantic proximity Read ↗

Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.Semantic proximity Read ↗

Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1.Semantic proximity Read ↗

Epithelial Glutamate Retention Protects against ColitisSemantic proximity Read ↗

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.Semantic proximity Read ↗

Creatine-supplemented diet extends Purkinje cell survival in spinocerebellar ataxia type 1 transgenic mice but does not prevent the ataxic phenotype.Semantic proximity Read ↗

The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese.Semantic proximity Read ↗

The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.