Article

Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytes

2024-07-20

Abstract excerpt

<h4>ABSTRACT</h4> Friedreich’s ataxia (FRDA) is a neurodegenerative disorder characterized by severe neurological signs affecting both the peripheral and central nervous system, caused by reduced levels of the frataxin protein (FXN). While several studies highlight cellular dysfunctions in neurons and various other cell types, there is limited information on the effects of FXN depletion in astrocytes and on the p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 039a4cc8-fd36-5bef-aad5-e2036d8dd362
DOI: 10.1101/2024.07.19.604129

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Altered calcium responses and antioxidant properties in Friedreich’s ataxia-like cerebellar astrocytesDOI 10.1101/2024.07.19.604129Read

'Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich's ataxia'.Semantic proximity Read

Frataxin knockdown in human astrocytes triggers cell death and the release of factors that cause neuronal toxicitySemantic proximity Read

Astrocyte dysfunction and neuronal network hyperactivity in a CRISPR engineered pluripotent stem cell model of frontotemporal dementiaSemantic proximity Read

Glial cell activation precedes neurodegeneration in the cerebellar cortex of the YG8-800 murine model of Friedreich’s ataxiaSemantic proximity Read

Friedreich ataxia-induced pluripotent stem cell-derived neurons show a cellular phenotype that is corrected by a benzamide HDAC inhibitor.Semantic proximity Read

Mitochondrial dysfunction induced by frataxin deficiency is associated with cellular senescence and abnormal calcium metabolismSemantic proximity Read

Neuroinflammation in Friedreich’s AtaxiaSemantic proximity Read

Pathophysiogical and therapeutic progress in Friedreich ataxia.Semantic proximity Read

Single-nuclei RNA sequencing uncovers non-cell autonomous changes in cerebellar astrocytes and oligodendrocytes that may contribute to Spinocerebellar Ataxia Type 1 (SCA1) pathogenesisSemantic proximity Read

Expression of familial A lzheimer disease presenilin 1 gene attenuates vesicle traffic and reduces peptide secretion in cultured astrocytes devoid of pathologic tissue environmentSemantic proximity Read

IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic <i>SNCA</i> mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium releaseSemantic proximity Read

Excision of Expanded GAA Repeats Alleviates the Molecular Phenotype of Friedreich's Ataxia.Semantic proximity Read