Article

ATM phosphorylation of CD98HC increases antiporter membrane localization and prevents chronic toxic glutamate accumulation in Ataxia telangiectasia

2024-09-05

Abstract excerpt

<title>Abstract</title> <p>Ataxia telangiectasia (A-T) is a rare genetic disorder characterized by neurological defects, immunodeficiency, cancer predisposition, radiosensitivity, decreased blood vessel integrity, and diabetes. ATM, the protein mutated in A-T, responds to DNA damage and oxidative stress, but its functional relationship to the progressive clinical manifestation of A-T is not understood. CD98HC cha...

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Literature Corpus work: 83a80618-1a94-5798-a569-3c4535b8e126
DOI: 10.21203/rs.3.rs-4947457/v1

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