Article
The in vitro uptake of glutamate in GLAST and GLT-1 transfected mutant CHO-K1 cells is inhibited by manganese.
Biological trace element research - 1 Dec 2005
Mutkus Lysette, Aschner Judy L, Fitsanakis Vanessa, Aschner Michael
Abstract excerpt
In the central nervous system (CNS), extracellular concentrations of amino acids (e.g., aspartate, glutamate) and divalent metals (e.g., zinc, copper, manganese) are primarily regulated by astrocytes. Adequate glutamate homeostasis and control over extracellular concentrations of these excitotoxic amino acids are essential for the normal functioning of the brain. Not only is glutamate of central importance for...
Topics
- Amino Acids
- Animals
- Astrocytes
- Brain
- CHO Cells
- Cells, Cultured
- Central Nervous System
- Chlorides
- Cricetinae
- D-Aspartic Acid
- Excitatory Amino Acid Transporter 1
- Excitatory Amino Acid Transporter 2
- Glutamates
- Glutamic Acid