Article
Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.
Nature neuroscience - 1 Jan 2006
Aoyama Koji, Suh Sang Won, Hamby Aaron M, Liu Jialing, Chan Wai Yee, Chen Yongmei, Swanson Raymond A
Abstract excerpt
Uptake of the neurotransmitter glutamate is effected primarily by transporters expressed on astrocytes, and downregulation of these transporters leads to seizures and neuronal death. Neurons also express a glutamate transporter, termed excitatory amino acid carrier-1 (EAAC1), but the physiological function of this transporter remains uncertain. Here we report that genetically EAAC1-null (Slc1a1(-/-)) mice have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.