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Article

The antioxidant glutathione protects against enteric neuron death in situ, but its depletion is protective during colitis.

American journal of physiology. Gastrointestinal and liver physiology - 1 Jan 2018

Brown Isola A M, Gulbransen Brian D

Abstract excerpt

Enteric glia play an important neuroprotective role in the enteric nervous system (ENS) by producing neuroprotective compounds such as the antioxidant reduced glutathione (GSH). The specific cellular pathways that regulate glial production of GSH and how these pathways are altered during, or contribute to, neuroinflammation in situ and in vivo are not fully understood. We investigated this issue using...

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Identifiers

PMID: 28882823
DOI: 10.1152/ajpgi.00165.2017
PMCID: PMC5866372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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