Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.

Neurobiology of disease - 1 Mar 2012

Aoyama Koji, Wang Fan, Matsumura Nobuko, Kiyonari Hiroshi, Shioi Go, Tanaka Karo, Kinoshita Chisato, Kikuchi-Utsumi Kazue, Watabe Masahiko, Nakaki Toshio

Abstract excerpt

Glutathione (GSH) is an important neuroprotective molecule in the brain. The strategy to increase neuronal GSH level is a promising approach to the treatment of neurodegenerative diseases. However, the regulatory mechanism by which neuron-specific GSH synthesis is facilitated remains elusive. Glutamate transporter-associated protein 3-18 (GTRAP3-18) is an endoplasmic reticulum protein interacting with excitatory...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exploratory Behavior
Share to gamma-Aminobutyric Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glial Fibrillary Acidic Protein

Share to Glutathione

Share to Glycine

Share to Maze Learning

Share to Nitric Oxide Donors

Share to Phosphopyruvate Hydratase

Source

Identifiers

PMID: 22210510
DOI: 10.1016/j.nbd.2011.12.016

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Increased neuronal glutathione and neuroprotection in GTRAP3-18-deficient mice.PMID 22210510Read ↗

Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse.Semantic proximity Read ↗

Prion protein regulates glutathione metabolism and neural glutamate and cysteine uptake via excitatory amino acid transporter 3.Semantic proximity Read ↗

Molecular mechanisms of excitotoxicity and their relevance to the pathogenesis of neurodegenerative diseases—an updateSemantic proximity Read ↗

Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain.Semantic proximity Read ↗

Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthoodSemantic proximity Read ↗

Prevention of age-related truncation of γ-glutamylcysteine ligase catalytic subunit (GCLC) delays cataract formation.Semantic proximity Read ↗

Glutamate Excitotoxicity and NeurodegenerationSemantic proximity Read ↗

Region- and age-specific changes in glutamate transport in the AβPP23 mouse model for Alzheimer's disease.Semantic proximity Read ↗

Mitochondrial GSH replenishment as a potential therapeutic approach for Niemann Pick type C disease.Semantic proximity Read ↗

Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis.Semantic proximity Read ↗

Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease.Semantic proximity Read ↗

Loss of system x(c)- does not induce oxidative stress but decreases extracellular glutamate in hippocampus and influences spatial working memory and limbic seizure susceptibility.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.