Article

Epithelial Glutamate Retention Protects against Colitis

2026-04-21

Abstract excerpt

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that encompasses ulcerative colitis and Crohn’s disease. Here we identify the cystine/glutamate antiporter xCT as being markedly upregulated in the inflamed intestinal epithelium of patients with IBD. To clarify its functional contribution to disease pathogenesis, we performed genetic loss-of-function study and found...

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Literature Corpus work: 4901956f-3296-5598-ba97-7be1bb9eed0f
DOI: 10.64898/2026.04.18.718419

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