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Article

Calculation of exact p-values when SNPs are tested using multiple genetic models.

BMC genetics - 20 Jun 2014

Talluri Rajesh, Wang Jian, Shete Sanjay

Abstract excerpt

BACKGROUND: Several methods have been proposed to account for multiple comparisons in genetic association studies. However, investigators typically test each of the SNPs using multiple genetic models. Association testing using the Cochran-Armitage test for trend assuming an additive, dominant, or recessive genetic model, is commonly performed. Thus, each SNP is tested three times. Some investigators report the...

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PMID: 24950707
DOI: 10.1186/1471-2156-15-75
PMCID: PMC4076502

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