Article
Asymptotic tests of association with multiple SNPs in linkage disequilibrium.
Genetic epidemiology - 1 Sept 2009
Pan Wei
Abstract excerpt
We consider detecting associations between a trait and multiple single nucleotide polymorphisms (SNPs) in linkage disequilibrium (LD). To maximize the use of information contained in multiple SNPs while minimizing the cost of large degrees of freedom (DF) in testing multiple parameters, we first theoretically explore the sum test derived under a working assumption of a common association strength between the...
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