Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of HMGCR alternative splicing in statin efficacy.

Trends in cardiovascular medicine - 1 Jul 2009

Medina Marisa Wong, Krauss Ronald M

Abstract excerpt

Statins, or 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) inhibitors, are widely prescribed to lower plasma cholesterol levels and reduce cardiovascular disease risk. Despite the well-documented efficacy of statins, there is large interindividual variation in response. Using a panel of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Cell Line, Transformed
Share to Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hydroxymethylglutaryl CoA Reductases

Share to Lymphocytes

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 20005478
DOI: 10.1016/j.tcm.2009.10.003
PMCID: PMC2805071

Genes

HMGCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20005478-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of HMGCR alternative splicing in statin efficacy.PMID 20005478Read ↗

Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin.Semantic proximity Read ↗

The relationship between HMGCR genetic variation, alternative splicing, and statin efficacy.Semantic proximity Read ↗

HNRNPA1 regulates HMGCR alternative splicing and modulates cellular cholesterol metabolism.Semantic proximity Read ↗

Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake.Semantic proximity Read ↗

Role of rs3846662 and HMGCR alternative splicing in statin efficacy and baseline lipid levels in familial hypercholesterolemia.Semantic proximity Read ↗

RHOA is a modulator of the cholesterol-lowering effects of statin.Semantic proximity Read ↗

Alternative splicing in the regulation of cholesterol homeostasis.Semantic proximity Read ↗

Combined influence of LDLR and HMGCR sequence variation on lipid-lowering response to simvastatin.Semantic proximity Read ↗

Variation in the 3-hydroxyl-3-methylglutaryl coenzyme a reductase gene is associated with racial differences in low-density lipoprotein cholesterol response to simvastatin treatment.Semantic proximity Read ↗

Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13.Semantic proximity Read ↗

Sterol-regulatory element-binding protein (SREBP)-2 contributes to polygenic hypercholesterolaemia.Semantic proximity Read ↗

MicroRNA-27a is a key modulator of cholesterol biosynthesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.