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Article

Influence of 6 genetic variants on the efficacy of statins in patients with dyslipidemia.

Journal of clinical laboratory analysis - 1 Oct 2018

Cano-Corres Ruth, Candás-Estébanez Beatriz, Padró-Miquel Ariadna, Fanlo-Maresma Marta, Pintó Xavier, Alía-Ramos Pedro

Abstract excerpt

BACKGROUND: Patients with dyslipidemia are often treated with statins to reduce lipids and hence cardiovascular risk, but treatment response is variable, partly due to genetic factors. METHODS: We studied the influence of 6 gene variants (APOE c.526C > T (APOE2), APOE c.388T > C (APOE4), SLCO1B1 c.521T > C, CYP3A4 c.-392G > A, HMGCR c.1564-106A > G, and LPA c.3947 + 467T > C) on statin efficacy assessing 2...

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Share to Cholesterol
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HMGCR gene

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Hydroxymethylglutaryl CoA Reductases

Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 29732606
DOI: 10.1002/jcla.22566
PMCID: PMC6817082

Genes

HMGCR
APOE
LPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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