Article

Active site assembly by SMG5 as a mechanism for SMG6 endonuclease licensing in nonsense-mediated mRNA decay

2025-12-28

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a conserved eukaryotic surveillance pathway that eliminates transcripts containing premature termination codons (PTCs). While the recognition phase of NMD is well characterised, the effector step – how targeted mRNAs are nucleolytically degraded – remains incompletely understood. In metazoans, NMD employs an endonucleolytic route mediated by SMG6, a PIN-domain nuclease, alongs...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9c9793c3-20d3-5ff1-b6b4-70eb92e3faf9
DOI: 10.64898/2025.12.27.695470

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Active site assembly by SMG5 as a mechanism for SMG6 endonuclease licensing in nonsense-mediated mRNA decayDOI 10.64898/2025.12.27.695470Read

Composite SMG5-SMG6 PIN domain formation is essential for NMD.Semantic proximity Read

A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.Semantic proximity Read

SMG7 acts as a molecular link between mRNA surveillance and mRNA decay.Semantic proximity Read

Identification and structural analysis of the Schizosaccharomyces pombe SMN complex.Semantic proximity Read

Negative cooperativity between Gemin2 and RNA provides insights into RNA selection and the SMN complex's release in snRNP assemblySemantic proximity Read

SMG1:SMG8:SMG9-complex integrity maintains robustness of nonsense-mediated mRNA decaySemantic proximity Read

m6A in the coding sequence: linking deposition, translation, and decaySemantic proximity Read

Sm complex assembly and 5' cap trimethylation promote selective processing of snRNAs by the 3' exonuclease TOE1.Semantic proximity Read

Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.Semantic proximity Read

In Vitro Cross-Linking MS Reveals SMG1-UPF2-SMG7 Assembly as Molecular Partners within the NMD Surveillance.Semantic proximity Read

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read

Protein Functional Effector (pfe) Noncoding RNAS are Identical to Fragments from Various Noncoding RNAsSemantic proximity Read