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Article

Driver Gene and Novel Mutations in Asbestos-Exposed Lung Adenocarcinoma and Malignant Mesothelioma Detected by Exome Sequencing.

Lung - 1 Feb 2016

Mäki-Nevala Satu, Sarhadi Virinder Kaur, Knuuttila Aija, Scheinin Ilari, Ellonen Pekka, Lagström Sonja, Rönty Mikko, Kettunen Eeva, Husgafvel-Pursiainen Kirsti, Wolff Henrik, Knuutila Sakari

Abstract excerpt

BACKGROUND: Asbestos is a carcinogen linked to malignant mesothelioma (MM) and lung cancer. Some gene aberrations related to asbestos exposure are recognized, but many associated mutations remain obscure. We performed exome sequencing to determine the association of previously known mutations (driver gene mutations) with asbestos and to identify novel mutations related to asbestos exposure in lung adenocarcinoma...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mesothelioma, Malignant

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Source

Identifiers

PMID: 26463840
DOI: 10.1007/s00408-015-9814-7

Genes

BAP1
KRAS
BRAF
MRPL1
SDK1
COPG1
CUL1
EGFR
EPHA1
EPHB1
ERBB2
HRAS
MET
NRAS
STK11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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