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Article

Human and mouse model cognitive phenotypes in Down syndrome: implications for assessment.

Progress in brain research - 1 Jan 2012

Edgin Jamie O, Mason Gina M, Spanò Goffredina, Fernández Andrea, Nadel Lynn

Abstract excerpt

The study of cognitive function in Down syndrome (DS) has advanced rapidly in the past decade. Mouse models have generated data regarding the neurological basis for the specific cognitive profile of DS (i.e., deficits in aspects of hippocampal, prefrontal, and cerebellar function) and have uncovered pharmacological treatments with the potential to affect this phenotype. Given this progress, the field is at a...

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PMID: 22541291
DOI: 10.1016/B978-0-444-54299-1.00007-8

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