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Article

Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain.

Oncotarget - 8 Dec 2015

Garcia-Heredia Jose M, Carnero Amancio

Abstract excerpt

Otto Warburg observed that cancer cells derived their energy from aerobic glycolysis by converting glucose to lactate. This mechanism is in opposition to the higher energy requirements of cancer cells because oxidative phosphorylation (OxPhos) produces more ATP from glucose. Warburg hypothesized that this phenomenon occurs due to the malfunction of mitochondria in cancer cells. The rediscovery of Warburg's...

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Identifiers

PMID: 26462158
DOI: 10.18632/oncotarget.6057
PMCID: PMC4747175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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