Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relevance of mitochondrial genetics and metabolism in cancer development.

Cold Spring Harbor perspectives in biology - 1 Feb 2013

Gasparre Giuseppe, Porcelli Anna Maria, Lenaz Giorgio, Romeo Giovanni

Abstract excerpt

Cancer cells are characterized in general by a decrease of mitochondrial respiration and oxidative phosphorylation, together with a strong enhancement of glycolysis, the so-called Warburg effect. The decrease of mitochondrial activity in cancer cells may have multiple reasons, related either to the input of reducing equivalents to the electron transfer chain or to direct alterations of the mitochondrial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Tumor
Share to DNA, Mitochondrial
Share to Mitochondria

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasms

Share to Oxidative Stress

Share to Reactive Oxygen Species

Source

Open in PubMed Open full text

Identifiers

PMID: 23378588
DOI: 10.1101/cshperspect.a011411
PMCID: PMC3552507

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relevance of mitochondrial genetics and metabolism in cancer development.PMID 23378588Read ↗

A mutation threshold distinguishes the antitumorigenic effects of the mitochondrial gene MTND1, an oncojanus function.Semantic proximity Read ↗

Mitochondria and Cancer.Semantic proximity Read ↗

Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs.Semantic proximity Read ↗

Mitochondria and cancer: a growing role in apoptosis, cancer cell metabolism and dedifferentiation.Semantic proximity Read ↗

Mitochondrial DNA mutations in cancer--from bench to bedside.Semantic proximity Read ↗

Mitochondria and cancer.Semantic proximity Read ↗

The awakening of an advanced malignant cancer: an insult to the mitochondrial genome.Semantic proximity Read ↗

Cancer Etiology: A Metabolic Disease Originating from Life’s Major Evolutionary Transition?Semantic proximity Read ↗

Mitochondrial DNA mutations induce mitochondrial biogenesis and increase the tumorigenic potential of Hodgkin and Reed-Sternberg cells.Semantic proximity Read ↗

Decoding Warburg's hypothesis: tumor-related mutations in the mitochondrial respiratory chain.Semantic proximity Read ↗

Molecular oncology focus - is carcinogenesis a 'mitochondriopathy'?Semantic proximity Read ↗

Mitochondria and cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.