Article
Identification and expansion of highly suppressive CD8(+)FoxP3(+) regulatory T cells after experimental allogeneic bone marrow transplantation.
Blood - 14 Jun 2012
Robb Renee J, Lineburg Katie E, Kuns Rachel D, Wilson Yana A, Raffelt Neil C, Olver Stuart D, Varelias Antiopi, Alexander Kylie A, Teal Bianca E, Sparwasser Tim, Hammerling Gunter J, Markey Kate A, Koyama Motoko, Clouston Andrew D, Engwerda Christian R, Hill Geoffrey R, MacDonald Kelli P A
Abstract excerpt
FoxP3(+) confers suppressive properties and is confined to regulatory T cells (T(reg)) that potently inhibit autoreactive immune responses. In the transplant setting, natural CD4(+) T(reg) are critical in controlling alloreactivity and the establishment of tolerance. We now identify an important CD8(+) population of FoxP3(+) T(reg) that convert from CD8(+) conventional donor T cells after allogeneic but not...
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