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Article

Adult Lineage-Restricted CNS Progenitors Specify Distinct Glioblastoma Subtypes.

Cancer cell - 12 Oct 2015

Alcantara Llaguno Sheila R, Wang Zilai, Sun Daochun, Chen Jian, Xu Jing, Kim Euiseok, Hatanpaa Kimmo J, Raisanen Jack M, Burns Dennis K, Johnson Jane E, Parada Luis F

Abstract excerpt

A central question in glioblastoma multiforme (GBM) research is the identity of the tumor-initiating cell, and its contribution to the malignant phenotype and genomic state. We examine the potential of adult lineage-restricted progenitors to induce fully penetrant GBM using CNS progenitor-specific inducible Cre mice to mutate Nf1, Trp53, and Pten. We identify two phenotypically and molecularly distinct GBM...

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Identifiers

PMID: 26461091
DOI: 10.1016/j.ccell.2015.09.007
PMCID: PMC4607935

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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