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Article

Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice

19 Oct 2012

Abstract excerpt

Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans. Here we show that gliomas can originate from differentiated cells in the central nervous system (CNS), including cortical neurons. Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice can give rise to malignant gliomas. All the...

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PMID: 23087000
DOI: 10.1126/science.1226929

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