Article

Perturbation of the mitochondrial import machinery by aggregation prone Tau affects organelle morphology and reduces neuronal complexity

2022-12-01

Abstract excerpt

Protein import into mitochondria is an intricate and highly conserved process essential for organellar biogenesis, and maintenance of its structure and function. Defects in the import apparatus impact the assembly of the respiratory chain and ATP synthase complexes required for oxidative phosphorylation, compromising the supply of ATP to the cytosol. The consequences of reduced bioenergetic function are particular...

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Literature Corpus work: edd50f7a-019c-5cb6-b2ed-22b6ecfed1bb
DOI: 10.1101/2022.11.30.518502

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