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Article

Mutated tau binds less avidly to microtubules than wildtype tau in living cells.

Journal of neuroscience research - 1 Feb 2001

Nagiec E W, Sampson K E, Abraham I

Abstract excerpt

Some forms of genetically inherited dementia, including frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17), are caused by mutations in tau. We have examined several mutations in the microtubule-binding portion of tau for their effect on microtubule binding, cellular distribution and cytoskeletal structure in mammalian cells. Using constructs coding for mutant (P301L and V337M) and...

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Identifiers

PMID: 11170176
DOI: 10.1002/1097-4547(20010201)63:3<268::AID-JNR1020>3.0.CO;2-E

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutated tau binds less avidly to microtubules than wildtype tau in living cells.PMID 11170176Read ↗

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