Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancer

26 Sept 2015

Abstract excerpt

The Homologous Recombination (HR) pathway is crucial for the repair of DNA double-strand breaks (DSBs) generated during DNA replication. Defects in HR repair have been linked to the initiation and development of a wide variety of human malignancies, and exploited in chemical, radiological and targeted therapies. In this study, we performed a personalised pathway analysis independently for four large sporadic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26456802
DOI: 10.1016/j.molonc.2015.09.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Personalised pathway analysis reveals association between DNA repair pathway dysregulation and chromosomal instability in sporadic breast cancerPMID 26456802Read ↗

Beyond BRCA: Discovery of novel causes and consequences of homologous recombination deficienciesSemantic proximity Read ↗

A pathway-based classification of human breast cancer.Semantic proximity Read ↗

Integrating breast tumor homologous recombination deficiency status to aid germline<i>BRCA1</i>and<i>BRCA2</i>variant classificationSemantic proximity Read ↗

Integrating Multi-omics Data to Dissect Mechanisms of DNA repair Dysregulation in Breast CancerSemantic proximity Read ↗

Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer.Semantic proximity Read ↗

Integrating breast tumour homologous recombination deficiency status to aid germline BRCA1 and BRCA2 variant classification.Semantic proximity Read ↗

Multi-scale characterisation of homologous recombination deficiency in breast cancerSemantic proximity Read ↗

Functional analysis-make or break for cancer predictability.Semantic proximity Read ↗

Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.Semantic proximity Read ↗

Identification of a histone family gene signature for predicting the prognosis of cervical cancer patientsSemantic proximity Read ↗

Oncogenic pathways in hereditary and sporadic breast cancer.Semantic proximity Read ↗

The shortest path is not the one you know: application of biological network resources in precision oncology research.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.