Article
A pathway-based classification of human breast cancer.
Proceedings of the National Academy of Sciences of the United States of America - 13 Apr 2010
Gatza Michael L, Lucas Joseph E, Barry William T, Kim Jong Wook, Wang Quanli, Crawford Matthew D, Datto Michael B, Kelley Michael, Mathey-Prevot Bernard, Potti Anil, Nevins Joseph R
Abstract excerpt
The hallmark of human cancer is heterogeneity, reflecting the complexity and variability of the vast array of somatic mutations acquired during oncogenesis. An ability to dissect this heterogeneity, to identify subgroups that represent common mechanisms of disease, will be critical to understanding the complexities of genetic alterations and to provide a framework to develop rational therapeutic strategies. Here,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.