Oncogenic pathways in hereditary and sporadic breast cancer.

doi:10.1016/j.maturitas.2004.06.005

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Article

Oncogenic pathways in hereditary and sporadic breast cancer.

Maturitas - 24 Sept 2004

Kenemans P, Verstraeten R A, Verheijen R H M

Abstract excerpt

Cancer is a genetic disease. Breast cancer tumorigenesis can be described as a multi-step process in which each step is thought to correlate with one or more distinct mutations in major regulatory genes. The question addressed is how far a multi-step progression model for sporadic breast cancer would differ from that for hereditary breast cancer. Hereditary breast cancer is characterized by an inherited...

Topics

Breast Neoplasms
Cell Transformation, Neoplastic
Disease Progression
Female
Genetic Predisposition to Disease
Humans
Models, Genetic
Mutation

Source

Open in PubMed

Identifiers

PMID: 15351094
DOI: 10.1016/j.maturitas.2004.06.005

Genes

BRCA1
BRCA2
CCND1
EMSY
ERBB2
MYC
PTEN

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