Article
Genomic profiling of breast tumours in relation to BRCA abnormalities and phenotypes.
Breast cancer research : BCR - 1 Jan 2009
Stefansson Olafur Andri, Jonasson Jon Gunnlaugur, Johannsson Oskar Thor, Olafsdottir Kristrun, Steinarsdottir Margret, Valgeirsdottir Sigridur, Eyfjord Jorunn Erla
Abstract excerpt
INTRODUCTION: Germline mutations in the BRCA1 and BRCA2 genes account for a considerable fraction of familial predisposition to breast cancer. Somatic mutations in BRCA1 and BRCA2 have not been found and the involvement of these genes in sporadic tumour development therefore remains unclear. METHODS: The study group consisted of 67 primary breast tumours with and without BRCA1 or BRCA2 abnormalities. Genomic...
Topics
- Biomarkers, Tumor
- Breast Neoplasms
- Cluster Analysis
- Comparative Genomic Hybridization
- Female
- Gene Dosage
- Gene Expression Profiling
- Genes, BRCA1
- Genes, BRCA2
- Genomic Instability
- Genotype
- Humans
- Oligonucleotide Array Sequence Analysis