Article
Bayesian integration of genetics and epigenetics detects causal regulatory SNPs underlying expression variability.
Nature communications - 12 Oct 2015
Das Avinash, Morley Michael, Moravec Christine S, Tang W H W, Hakonarson Hakon, Margulies Kenneth B, Cappola Thomas P, Jensen Shane, Hannenhalli Sridhar
Abstract excerpt
The standard expression quantitative trait loci (eQTL) detects polymorphisms associated with gene expression without revealing causality. We introduce a coupled Bayesian regression approach--eQTeL, which leverages epigenetic data to estimate regulatory and gene interaction potential, and identifies combination of regulatory single-nucleotide polymorphisms (SNPs) that explain the gene expression variance. On human...
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