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Article

Dissecting the regulatory architecture of gene expression QTLs.

Genome biology - 31 Jan 2012

Gaffney Daniel J, Veyrieras Jean-Baptiste, Degner Jacob F, Pique-Regi Roger, Pai Athma A, Crawford Gregory E, Stephens Matthew, Gilad Yoav, Pritchard Jonathan K

Abstract excerpt

BACKGROUND: Expression quantitative trait loci (eQTLs) are likely to play an important role in the genetics of complex traits; however, their functional basis remains poorly understood. Using the HapMap lymphoblastoid cell lines, we combine 1000 Genomes genotypes and an extensive catalogue of human functional elements to investigate the biological mechanisms that eQTLs perturb. RESULTS: We use a Bayesian...

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Identifiers

PMID: 22293038
DOI: 10.1186/gb-2012-13-1-r7
PMCID: PMC3334587

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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