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Article

Hypoxia-induced endoplasmic reticulum stress characterizes a necrotic phenotype of pancreatic cancer.

Oncotarget - 13 Oct 2015

Kong Bo, Cheng Tao, Wu Weiwei, Regel Ivonne, Raulefs Susanne, Friess Helmut, Erkan Mert, Esposito Irene, Kleeff Jörg, Michalski Christoph W

Abstract excerpt

Stromal fibrosis and tissue necrosis are major histological sequelae of hypoxia. The hypoxia-to-fibrosis sequence is well-documented in pancreatic ductal adenocarcinoma (PDAC). However, hypoxic and necrotic PDAC phenotypes are insufficiently characterized. Recently, reduction of tuberous sclerosis expression in mice together with oncogenic Kras demonstrated a rapidly metastasizing phenotype with histologically...

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Source

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Identifiers

PMID: 26452217
DOI: 10.18632/oncotarget.5168
PMCID: PMC4741665

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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