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Article

Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexia

2025-09-18

Abstract excerpt

Cachexia is a debilitating syndrome marked by progressive skeletal muscle wasting, commonly affecting cancer patients, particularly those with pancreatic cancer. Despite its clinical significance, the molecular mechanisms underlying cancer cachexia remain poorly understood. In this study, we utilized single-nucleus RNA sequencing (snRNA-seq) and bulk RNA-seq, complemented by biochemical and histological analyses,...

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Identifiers and source

Literature Corpus work
81ddf22b-4438-5d43-9781-de3ee0738e40
DOI
10.1101/2025.09.15.676415
Open publication

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Fiber-type vulnerability and proteostasis reprogramming in skeletal muscle during pancreatic cancer cachexiaDOI 10.1101/2025.09.15.676415
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