Article
Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis.
Gastroenterology - 1 Nov 2020
Tiwari Ashutosh, Tashiro Kojiro, Dixit Ajay, Soni Aditi, Vogel Keianna, Hall Bryan, Shafqat Iram, Slaughter Joseph, Param Nesteen, Le An, Saunders Emily, Paithane Utkarsha, Garcia Guillermina, Campos Alexandre Rosa, Zettervall Jon, Carlson Marjorie, Starr Timothy K, Marahrens York, Deshpande Aniruddha J, Commisso Cosimo, Provenzano Paolo P, Bagchi Anindya
Abstract excerpt
BACKGROUND & AIMS: Pancreatic ductal adenocarcinomas (PDACs) are hypovascular, resulting in the up-regulation of hypoxia inducible factor 1 alpha (HIF1A), which promotes the survival of cells under low-oxygen conditions. We studied the roles of HIF1A in the development of pancreatic tumors in mice. METHODS: We performed studies with KrasLSL-G12D/+;Trp53LSL-R172H/+;Pdx1-Cre (KPC) mice, KPC mice with labeled...
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