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Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

2025-09-08

Abstract excerpt

Systemic therapies are the standard of care for most pancreatic ductal adenocarcinoma (PDAC) patients but provide limited benefit due to pervasive resistance. The fibrotic tumor microenvironment (TME) is thought to drive resistance by restricting perfusion and drug delivery. Here, we show that therapeutically relevant drug concentrations are achieved even in poorly perfused, therapy-resistant murine PDAC tumors, i...

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Identifiers and source

Literature Corpus work
2988a459-9808-5dca-b315-0e5c5bd786e4
DOI
10.1101/2025.09.04.673818
Open publication

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Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancerDOI 10.1101/2025.09.04.673818
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