Tumor necrosis associates with aggressive breast cancer features, increased hypoxia signaling and reduced patient survival.

Abstract excerpt

In the growing tumor, hypoxia may lead to tumor necrosis which is associated with more aggressive tumor features and reduced patient survival. However, there are shortcomings in our understanding of biological features and clinical significance linked to tumor necrosis. We therefore analyzed transcriptome mRNA expression profiles from primary breast tumors from TCGA and METABRIC (n = 2289) including TCGA...

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