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Article

Autophagy mediates survival of pancreatic tumour‐initiating cells in a hypoxic microenvironment

19 Jan 2012

Abstract excerpt

Involvement of dysregulated autophagy in cancer growth and progression has been shown in different tumour entities, including pancreatic ductal adenocarcinoma (PDA). PDA is an extremely aggressive tumour characterized by a small population of highly therapy-resistant cancer stem cells (CSCs) capable of self-renewal and migration. We examined whether autophagy might be involved in the survival of CSCs despite...

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PMID: 22262369
DOI: 10.1002/path.3994

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