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Article

Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster.

PloS one - 1 Jan 2015

Praxenthaler Heiko, Smylla Thomas K, Nagel Anja C, Preiss Anette, Maier Dieter

Abstract excerpt

Hairless (H) is the major antagonist within the Notch signalling pathway of Drosophila melanogaster. By binding to Suppressor of Hairless [Su(H)] and two co-repressors, H induces silencing of Notch target genes in the absence of Notch signals. We have applied genomic engineering to create several new H alleles. To this end the endogenous H locus was replaced with an attP site by homologous recombination, serving...

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Identifiers

PMID: 26448463
DOI: 10.1371/journal.pone.0140007
PMCID: PMC4598140

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster.PMID 26448463Read ↗

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