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Article

In vivo structure-function analysis of Drosophila Hairless.

Mechanisms of development - 1 Sept 1997

Maier D, Marquart J, Thompson-Fontaine A, Beck I, Wurmbach E, Preiss A

Abstract excerpt

Hairless plays an important role as the major antagonist in the Notch signalling pathway in Drosophila. It appears to be a direct inhibitor of the signal transducer Su(H). Hairless encodes a pioneer protein which was dissected in a structure-function analysis; a series of deletion constructs was tested for wild type and gain of function activity in the fly as well as for Su(H) binding. Thereby, the Hairless...

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PMID: 9347918
DOI: 10.1016/s0925-4773(97)00117-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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In vivo structure-function analysis of Drosophila Hairless.PMID 9347918Read ↗

Dissecting the mechanisms of suppressor of hairless function.Semantic proximity Read ↗

Molecular analysis of the notch repressor-complex in Drosophila: characterization of potential hairless binding sites on suppressor of hairless.Semantic proximity Read ↗

Membrane-Anchored Hairless Protein Restrains Notch Signaling Activity.Semantic proximity Read ↗

Genetic screen for modifiers of the rough eye phenotype resulting from overexpression of the Notch antagonist hairless in Drosophila.Semantic proximity Read ↗

Gain of function notch phenotypes associated with ectopic expression of the Su(H) C-terminal domain illustrate separability of Notch and hairless-mediated activities.Semantic proximity Read ↗

Genetic and Molecular Interactions between HΔCT, a Novel Allele of the Notch Antagonist Hairless, and the Histone Chaperone Asf1 in Drosophila melanogaster.Semantic proximity Read ↗

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless.Semantic proximity Read ↗

Generation of New Hairless Alleles by Genomic Engineering at the Hairless Locus in Drosophila melanogaster.Semantic proximity Read ↗

Structure and expression of the hairless gene of mice.Semantic proximity Read ↗

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Mutation of potential MAPK phosphorylation sites in the Notch antagonist Hairless.Semantic proximity Read ↗

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