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Article

Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.

PloS one - 1 Jan 2015

Waraya Mina, Yamashita Keishi, Ema Akira, Katada Natsuya, Kikuchi Shiro, Watanabe Masahiko

Abstract excerpt

BACKGROUND: A comprehensive search for DNA methylated genes identified candidate tumor suppressor genes that have been proven to be involved in the apoptotic process of the p53 pathway. In this study, we investigated p53 mutation in relation to such epigenetic alteration in primary gastric cancer. METHODS: The methylation profiles of the 3 genes: PGP9.5, NMDAR2B, and CCNA1, which are involved in the p53 tumor...

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Share to Disease-Free Survival
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenesis, Genetic

Share to Kaplan-Meier Estimate

Share to Polymorphism, Single-Stranded Conformational

Share to Stomach Neoplasms

Share to Tumor Suppressor Protein p53

Share to Ubiquitin Thiolesterase

Source

Open in PubMed Open full text

Identifiers

PMID: 26447864
DOI: 10.1371/journal.pone.0139902
PMCID: PMC4598091

Genes

CCNA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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