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Article

Inverse correlation between cyclin A1 hypermethylation and p53 mutation in head and neck cancer identified by reversal of epigenetic silencing.

Cancer research - 1 Sept 2004

Tokumaru Yutaka, Yamashita Keishi, Osada Motonobu, Nomoto Shuji, Sun Dong-Il, Xiao Yan, Hoque Mohammad Obaidul, Westra William H, Califano Joseph A, Sidransky David

Abstract excerpt

Aberrant promoter hypermethylation of tumor suppressor genes is proposed to be a common feature of primary cancer cells. We recently developed a pharmacological unmasking microarray approach to screen unknown tumor suppressor gene candidates epigenetically silenced in human cancers. In this study, we applied this method to identify such genes in head and neck squamous cell carcinoma (HNSCC). We identified 12...

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Share to Carcinoma, Squamous Cell
Share to Cyclin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 15342377
DOI: 10.1158/0008-5472.CAN-04-0993

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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