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Article

Progranulin genetic polymorphisms influence progression of disability and relapse recovery in multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Jul 2016

Vercellino Marco, Fenoglio Chiara, Galimberti Daniela, Mattioda Alessandra, Chiavazza Carlotta, Binello Eleonora, Pinessi Lorenzo, Giobbe Dario, Scarpini Elio, Cavalla Paola

Abstract excerpt

BACKGROUND: Progranulin (GRN) is a multifunctional protein involved in inflammation and repair, and also a neurotrophic factor critical for neuronal survival. Progranulin is strongly expressed in multiple sclerosis (MS) brains by macrophages and microglia. METHODS: In this study we evaluated GRN genetic variability in 400 MS patients, in correlation with clinical variables such as disease severity and relapse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26447062
DOI: 10.1177/1352458515610646

Genes

GRN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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