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Article

Progranulin Levels in Plasma and Cerebrospinal Fluid in Granulin Mutation Carriers

21 Jul 2016

Abstract excerpt

<b><i>Background:</i></b> Pathogenic mutations in the granulin gene <i>(GRN)</i> are causative in 5-10% of patients with frontotemporal dementia (FTD), mostly leading to reduced progranulin protein (PGRN) levels. Upcoming therapeutic trials focus on enhancing PGRN levels. <b><i>Methods:</i></b> Fluctuations in plasma PGRN (n = 41) and its relationship...

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PMID: 27703466
DOI: 10.1159/000447738

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