Article
Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2009
Fenoglio Chiara, Galimberti Daniela, Cortini Francesca, Kauwe John S K, Cruchaga Carlos, Venturelli Eliana, Villa Chiara, Serpente Maria, Scalabrini Diego, Mayo Kevin, Piccio Laura M, Clerici Francesca, Albani Diego, Mariani Claudio, Forloni Gianluigi, Bresolin Nereo, Goate Alison M, Scarpini Elio
Abstract excerpt
Mutations in the progranulin gene (GRN), causative for Frontotemporal Lobar Degeneration with ubiquitin-immunoreactive neuronal inclusions (FTLD-U), could also be associated with Alzheimer's disease (AD). The influence of GRN genetic variability on susceptibility to AD and on expression levels in a series of neuropathologically-confirmed AD patients as well as in peripheral mononuclear cells (PBMC) and in cells...
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