Article
Common genetic variation within miR-146a predicts disease onset and relapse in multiple sclerosis.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology - 1 Feb 2018
Zhou Yuan, Chen Ming, Simpson Steve, Lucas Robyn M, Charlesworth Jac C, Blackburn Nicholas, van der Mei Ingrid, Ponsonby Anne-Louise, Taylor Bruce V
Abstract excerpt
Despite extensive studies focusing on the changes in expression of microRNAs (miRNAs) in multiple sclerosis (MS) compared to healthy controls, few studies have evaluated the association of genetic variants of miRNAs with MS clinical course. We investigated whether a functional polymorphism in the MS associated miR-146a gene predicted clinical course (hazard of conversion to MS and of relapse, and annualized...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.