Article
Progranulin gene variability increases the risk for primary progressive multiple sclerosis in males.
Genes and immunity - 1 Sept 2010
Fenoglio C, Scalabrini D, Esposito F, Comi C, Cavalla P, De Riz M, Martinelli V, Piccio L M, Venturelli E, Fumagalli G, Capra R, Collimedaglia L, Ghezzi A, Rodegher M E, Vercellino M, Leone M, Giordana M T, Bresolin N, Monaco F, Comi G, Scarpini E, Martinelli-Boneschi F, Galimberti D
Abstract excerpt
Progranulin (GRN) gene variability has been analyzed in a sample of 354 patients with multiple sclerosis (MS) compared with 343 controls. No significant differences were observed, but by stratifying according to MS subtypes, a significant increased frequency of the rs2879096 TT genotype was found in primary progressive MS (PPMS) patients versus controls (16.0 vs 3.5%, P=0.023, odds ratio (OR) 5.2, 95% confidence...
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